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Symbol
Name
ID 		Trp53
transformation related protein 53
MGI:98834
Phenotype annotations related to hematopoietic system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgA level
Increased circulating IgG level
Decreased circulating antibody level
Paraproteinemia
Anemia
Leukemia
Acute leukemia
Acute lymphoblastic leukemia
Acute myeloid leukemia
Lymphoma
Hodgkin lymphoma
Non-Hodgkin lymphoma
T-cell lymphoma
Multiple myeloma
Myelodysplasia
Splenomegaly
Hepatosplenomegaly
Disease(s) Associated with TP53
acute myeloid leukemia
Li-Fraumeni syndrome
Li-Fraumeni syndrome 1
mismatch repair cancer syndrome
multiple myeloma
myelodysplastic syndrome
pancreatic cancer

Mouse Phenotypes
hematopoietic system phenotype
abnormal thymocyte apoptosis
decreased thymocyte apoptosis
increased thymocyte apoptosis
decreased T cell apoptosis
decreased splenocyte apoptosis
decreased T cell proliferation
decreased hematopoietic stem cell proliferation
increased splenocyte proliferation
abnormal thymus morphology
increased thymus weight
small thymus
abnormal thymus physiology
hepatosplenomegaly
enlarged spleen
increased spleen weight
spleen hyperplasia
abnormal definitive hematopoiesis
abnormal common myeloid progenitor cell morphology
decreased common myeloid progenitor cell number
extramedullary hematopoiesis
anemia
macrocytic anemia
decreased bone marrow cell number
decreased erythroid progenitor cell number
abnormal megakaryocyte progenitor cell morphology
decreased erythrocyte cell number
decreased hematocrit
decreased neutrophil cell number
thrombocytopenia
increased large unstained cell number
decreased leukocyte cell number
increased leukocyte cell number
decreased hematopoietic stem cell number
pancytopenia
increased hematopoietic stem cell number
abnormal lymphocyte morphology
abnormal spleen morphology
decreased spleen red pulp amount
decreased spleen weight
small spleen
spleen hypoplasia
abnormal spleen white pulp morphology
abnormal spleen marginal zone morphology
abnormal hematopoietic system physiology
abnormal hematopoietic stem cell physiology
Availability Mouse Genotype
Gt(ROSA)26Sortm1.1(CAG-Trp53*,-EGFP)Medz/Gt(ROSA)26Sortm1.1(CAG-Trp53*,-EGFP)Medz
Trp53tm1.1Manf/Trp53tm1.1Manf
Trp53tm1.1Thst/Trp53tm1.1Thst
Trp53tm1.1Tldo/Trp53tm1.1Tldo
Trp53tm1.1Wgu/Trp53tm1.1Wgu
Trp53tm1.2Awbr/Trp53tm1.2Awbr
Trp53tm1b(EUCOMM)Hmgu/Trp53tm1b(EUCOMM)Hmgu
Trp53tm1Brd/Trp53tm1Brd
Trp53tm1Glo/Trp53tm1Glo
Trp53tm1Sia/Trp53tm1Sia
Trp53tm1Thst/Trp53tm1Thst
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Trp53)1Srn/0
Trp53tm1Tyj/Trp53tm1Tyj
Trp53tm1Xu/Trp53tm1Xu
Trp53tm1Yjc/Trp53tm1Yjc
Trp53tm2.1Snj/Trp53tm2.1Snj
Trp53tm2.1Wgu/Trp53tm2.1Wgu
Trp53tm2Wahl/Trp53tm2Wahl
Trp53tm2Xu/Trp53tm2Xu
Trp53tm7.1Xu/Trp53tm7.1Xu
Trp53tm1.1Thst/Trp53+
Trp53tm1.2Awbr/Trp53+
Trp53tm1Brd/Trp53tm8Xu
Trp53tm1Holl/Trp53tm7.1Xu
Trp53tm1Ldo/Trp53+
Trp53tm1Thst/Trp53+
Trp53tm1Thst/Trp53tm1.1Thst
Trp53tm1Tyj/Trp53+
Trp53tm1Tyj/Trp53tm1.1Umol
Trp53tm1Tyj/Trp53tm2.1Umol
Trp53tm3.1Glo/Trp53+
Trp53tm7.1Xu/Trp53+
Tg(Trp53)1Srn/0
Tg(Trp53)bSrn/0
Tg(Trp53A135V)L3Ber/0
Gt(ROSA)26Sortm1(CAG-Trp53*,-EGFP)Medz/Gt(ROSA)26Sor+
Tg(Nes-cre)1Wme/0  (conditional)		 *
Gt(ROSA)26Sortm1(CAG-Trp53*,-EGFP)Medz/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0  (conditional)
Gt(ROSA)26Sortm1(CAG-Trp53*,-EGFP)Medz/Gt(ROSA)26Sortm1(cre/ERT)Nat  (conditional) *
Tg(CMV-cre)1Cgn/0
Trp53tm4Att/Trp53+  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory